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New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status — New York, May 3–July 25, 2021 https://www.cdc.gov/mmwr/volumes/70/wr/mm7034e1.htm?s_cid=mm7034e1_w New study from New York First to assess vaccine protection against coronavirus infection in delta times Data for New York May 3 to July 25 N = 10.5 million Modest drop in vaccine effectiveness against lab confirmed infection May 3, 91.7% July 25, 79.8% But Age adjusted effectiveness against hospitalizations May 3, 91.9% to 95.3% July 25, 91.9% to 95.3% Factors Delta up from 2% to 80% Widespread relaxations Implications Currently authorized vaccines have high effectiveness against COVID-19 hospitalization, but effectiveness against new cases appears to have declined in recent months these findings support the implementation of a layered approach centered on vaccination, as well as other prevention strategies Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021 N = 85,593 weekly reports mRNA vaccines https://www.cdc.gov/mmwr/volumes/70/wr/mm7034e3.htm?s_cid=mm7034e3_w Effectiveness against infection declined in nursing homes as delta increased March, 75% June, 53% Vaccination for visitors and staff is crucial, additional doses of COVID-19 vaccine might be considered for nursing home and long-term care facility residents Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults — United States, March–July 2021 N = 1,129 diagnosed patients https://www.cdc.gov/mmwr/volumes/70/wr/mm7034e2.htm?s_cid=mm7034e2_w Analysis of patients at 21 hospitals After 2 doses of mRNA vaccine Across 18 states Substantial protection against hospitalizations No decline in protection against hospitalization over 24 weeks Effectiveness was steady at 86% percent Immunocompetent adults, 90% protection Remained constant during delta surge At 2 to 12 weeks after second dose, 86% At 13 to 24 weeks after second dose, 84% CDC director Rochelle Walensky https://www.washingtonpost.com/health/2021/08/18/covid-vaccine-effectiveness/ Examining numerous cohorts through the end of July and early August, three points are now very clear First, vaccine-induced protection against SARS-CoV-2 infection begins to decrease over time. Second, vaccine effectiveness against severe disease, hospitalization and death remains relatively high. And third, vaccine effectiveness is generally decreased against the delta variant

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